Unlocking the Power of Polyphenol Metabolites: How ACEND’s Ingredients Combat Chronic Inflammation
The small molecule polyphenols in ACEND, including quercetin, luteolin, dihydromyricetin, epicatechin, dihydroquercetin, thymoquinone, proanthocyanidins, and astaxanthin, undergo biotransformation that enhances their bioavailability and biological activity.
Date: February 12, 2025
Contributing Authors: Team TRILITY / ACEND
Unlocking the Power of Polyphenol Metabolites: How ACEND’s Ingredients Combat Chronic Inflammation
Chronic inflammation is a fundamental factor in the development of numerous diseases, including Crohn’s disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), Alzheimer’s, Parkinson’s, and various metabolic disorders. Polyphenols, integral components of ACEND, play a pivotal role in mitigating inflammation. Beyond their initial structures, these compounds undergo metabolic transformations in the gut and liver, producing bioactive metabolites that enhance their therapeutic effects. Understanding these metabolites is essential to fully appreciate ACEND’s efficacy in chronic inflammation prevention and disease mitigation.
How Polyphenols in ACEND Are Metabolized
The small molecule polyphenols present in ACEND—including quercetin, luteolin, dihydromyricetin, epicatechin, dihydroquercetin, thymoquinone, proanthocyanidins, and astaxanthin—undergo enzymatic and microbial metabolism. This process leads to the formation of metabolites with enhanced bioactivity and bioavailability. These metabolites effectively regulate inflammatory pathways, oxidative stress, and gut microbiome balance, all of which are critical factors in chronic disease prevention.
Key Metabolites and Their Anti-Inflammatory Actions
Quercetin Dihydrate
- Metabolites: Quercetin glucuronides, sulfate derivatives, dihydroquercetin
- Actions: Supports vascular function, reduces oxidative stress, modulates gut microbiota.
Luteolin
- Metabolites: Luteolin glucuronides, methyl-luteolin, phenolic acids
- Actions: Crosses the blood-brain barrier, inhibits neuroinflammation, regulates NF-κB pathways.
Dihydromyricetin
- Metabolites: Dihydroquercetin, myricetin derivatives, vanillic acid
- Actions: Enhances mitochondrial function, reduces oxidative stress, strengthens gut barrier integrity.
Epicatechin (Green Tea Extract)
- Metabolites: Epicatechin glucuronides, valerolactones, phenolic acids
- Actions: Improves vascular health, supports gut microbiota, reduces inflammation.
Dihydroquercetin (Taxifolin)
- Metabolites: Glucuronides, sulfated derivatives, dihydroxyphenylacetic acid
- Actions: Reduces vascular inflammation, supports neuroprotection, enhances gut health.
Thymoquinone (Black Cumin Seed Extract)
- Metabolites: Thymohydroquinone, dihydrothymoquinone
- Actions: Crosses the blood-brain barrier, supports liver detoxification, modulates immune response.
Proanthocyanidins (Grape Seed Extract)
- Metabolites: Valerolactones, phenylacetic acids, short-chain fatty acids (SCFAs) such as butyrate, propionate, acetate
- Actions: Reduces NF-κB activity, enhances gut barrier function, supports cardiovascular health.
Astaxanthin
- Metabolites: Astaxanthin esters, hydroxyl metabolites, retinoid-like compounds
- Actions: Crosses the blood-brain barrier, reduces oxidative stress, enhances immune function.
Why Polyphenol Metabolites Matter
Polyphenols in their native form offer significant health benefits; however, their metabolites often exhibit increased potency and bioavailability. Through interactions with gut microbiota and enzymatic conversion, these small molecules become even more effective in reducing inflammation, oxidative stress, and immune dysregulation. Their impact extends to:
- Neuroprotection: Reducing the risk of Alzheimer’s and Parkinson’s diseases.
- Gut Health Improvement: Strengthening gut integrity, modulating microbiota, alleviating symptoms of IBD and IBS.
- Cardiovascular Support: Enhancing circulation, reducing inflammation in blood vessels.
- Immune Modulation: Regulating cytokine production to control chronic inflammation.
ACEND: A Clinically-Optimized Medical Food
By harnessing polyphenols that undergo beneficial metabolic transformations, ACEND delivers bioavailable, clinically effective compounds targeting inflammation at its source. Its formulation is designed to maximize bioactivity, ensuring that small molecules and their gut-derived metabolites collaborate to provide a comprehensive therapeutic approach to chronic inflammation prevention.
Conclusion
The science of polyphenol metabolism highlights ACEND’s capacity to optimize gut health, enhance brain function, and reduce systemic inflammation. By supporting the body’s natural metabolic pathways, ACEND represents a progressive medical food solution for chronic inflammation prevention.
Note: Always consult with a healthcare professional before considering any treatment options or significant dietary changes.
References
- Pandey KB, Rizvi SI. “Plant polyphenols as dietary antioxidants in human health and disease.” Oxidative Medicine and Cellular Longevity, 2009.
- Ganesan, K., & Xu, B. (2017). Polyphenol-rich dry common beans (Phaseolus vulgaris L.) and their health benefits. International Journal of Molecular Sciences, 18(11), 2331. https://doi.org/10.3390/ijms18112331