ACEND

Unlocking the Power of Polyphenol Metabolites: How ACEND’s Ingredients Combat Chronic Inflammation

Polyphenols and their metabolites.

Unlocking the Power of Polyphenol Metabolites: How ACEND’s Ingredients Combat Chronic Inflammation

Chronic inflammation is a root cause of numerous diseases, including Crohn’s disease, IBD, IBS, Alzheimer’s, Parkinson’s, and metabolic disorders. Polyphenols, a key component of ACEND, play a critical role in mitigating inflammation, but their impact goes beyond their initial structure. Once ingested, these compounds undergo metabolic transformation in the gut and liver, producing bioactive metabolites that enhance their therapeutic effects. Understanding how these metabolites function provides deeper insight into ACEND’s ability to combat chronic inflammation and promote overall health.

Metabolites of Small Molecule Polyphenols in ACEND

The small molecule polyphenols in ACEND, including quercetin, luteolin, dihydromyricetin, epicatechin, dihydroquercetin, thymoquinone, proanthocyanidins, and astaxanthin, undergo biotransformation that enhances their bioavailability and biological activity. These metabolites target inflammatory pathways, regulate oxidative stress, and support gut and brain health.

1. Quercetin Dihydrate Metabolism

  • Primary Metabolites:
    • Quercetin glucuronides (Quercetin-3-O-glucuronide)
    • Quercetin sulfate
    • Dihydroquercetin (Taxifolin)
    • Phenylacetic acid derivatives
  • Health Benefits:
    • Enhances endothelial function and vascular health
    • Reduces oxidative stress and systemic inflammation
    • Modulates gut microbiota to prevent inflammation in the colon

2. Luteolin Metabolism

  • Primary Metabolites:
    • Luteolin glucuronides
    • Luteolin sulfate
    • Methyl-luteolin derivatives
    • Phenolic acids (p-Coumaric acid, Ferulic acid, Vanillic acid)
  • Health Benefits:
    • Crosses the blood-brain barrier to reduce neuroinflammation
    • Inhibits NF-κB and MAPK pathways, lowering inflammatory cytokines
    • Supports gut microbiome balance

3. Dihydromyricetin Metabolism

  • Primary Metabolites:
    • Dihydroquercetin (Taxifolin)
    • Myricetin glucuronides
    • Phenolic acids (Vanillic acid, Hippuric acid, Protocatechuic acid)
  • Health Benefits:
    • Enhances mitochondrial function and cognitive health
    • Reduces oxidative stress and inflammation in the brain
    • Strengthens gut barrier integrity

4. Epicatechin Metabolism (Green Tea Extract)

  • Primary Metabolites:
    • Epicatechin glucuronides
    • Epicatechin sulfate
    • Dihydroxyphenyl-γ-valerolactone
    • Short-chain phenolic acids (Ferulic acid, Vanillic acid, Protocatechuic acid)
  • Health Benefits:
    • Improves vascular health and endothelial function
    • Acts as a prebiotic, enhancing gut microbiome composition
    • Reduces systemic oxidative stress

5. Dihydroquercetin (Taxifolin) Metabolism

  • Primary Metabolites:
    • Glucuronide conjugates
    • Sulfated derivatives
    • Dihydroxyphenylacetic acid
  • Health Benefits:
    • Supports cardiovascular health by reducing inflammation in blood vessels
    • Enhances neuroprotection against oxidative damage
    • Modulates gut microbiota for improved digestion and immune function

6. Thymoquinone Metabolism (Black Cumin Seed Extract)

  • Primary Metabolites:
    • Hydroquinone derivatives
    • Thymohydroquinone (THQ)
    • Dihydrothymoquinone
  • Health Benefits:
    • Crosses the blood-brain barrier to reduce neuroinflammation
    • Supports liver detoxification and antioxidant activity
    • Modulates immune response to lower systemic inflammation

7. Proanthocyanidin Metabolism (Grape Seed Extract)

  • Primary Metabolites:
    • Dihydroxyphenyl-γ-valerolactone
    • Phenylacetic acids
    • Short-chain fatty acids (SCFAs – Butyrate, Propionate, Acetate)
  • Health Benefits:
    • Reduces inflammation via NF-κB inhibition
    • Enhances gut barrier integrity and microbiome diversity
    • Supports cardiovascular and cognitive health

8. Astaxanthin Metabolism

  • Primary Metabolites:
    • Astaxanthin esters
    • Astaxanthin hydroxyl metabolites
    • Retinoid-like compounds
  • Health Benefits:
    • Crosses the blood-brain barrier for neuroprotection
    • Reduces oxidative stress and inflammation in mitochondria
    • Supports immune function and skin health

Why Polyphenol Metabolites Matter

The transformation of polyphenols into bioactive metabolites is essential for maximizing their therapeutic benefits. Many of these metabolites are more potent than their parent compounds, allowing for enhanced:

  • Neuroprotection (reducing risk of Alzheimer’s, Parkinson’s, and cognitive decline)
  • Gut health improvement (strengthening gut barrier integrity and reducing inflammation in IBD, IBS, and Crohn’s disease)
  • Vascular health support (enhancing circulation, reducing blood vessel inflammation, and lowering cardiovascular disease risk)
  • Immune modulation (reducing excessive immune activation linked to chronic inflammatory diseases)

ACEND: A Metabolically-Optimized Medical Food

By leveraging polyphenols that undergo beneficial metabolic transformations, ACEND delivers bioavailable, clinically effective compounds to target inflammation at its root. The small molecules in ACEND, combined with prebiotic and microbiome-supporting metabolites, provide a comprehensive approach to chronic inflammation prevention and disease mitigation.

Note: Always consult with a healthcare professional before considering any treatment options or significant dietary changes.